Allopurinol inhibits the expression of biomarkers beta-catenin and NF-kappa B, and may be a colorectal cancer-preventive compound in patients with colorectal adenomas, according to recent results.In double blind, multicenter trial, researchers randomly assigned 73 adult patients with one or more colorectal adenomas to receive either placebo (n=24) or 100 mg allopurinol (n=24) or 300 mg allopurinol (n=25) daily for four weeks before polyp removal. Ki-67 labeling index in the adenomatous tissue was assessed before and after removal, along with immunohistochemical (HC) expression of NF-kappa B, beta-catenin, topoisomerase-II-alpha and terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) in polyps and the adjacent tissue.
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