Acitretin potentially effective treatment for cutaneous T-cell lymphoma

Acitretin therapy for patients with cutaneous T-cell lymphoma was well tolerated and potentially effective, according to study results.Researchers in Atlanta conducted a retrospective chart review of 32 patients with cutaneous T-cell lymphoma (CTCL; mean age, 56 years; 56% men) treated with acitretin at a tertiary care center. Twenty-nine patients had mycosis fungoides, two had Sézary syndrome and one had unspecified CTCL. At acitretin initiation, 3% of patients were stage IA CTCL, 69%, stage IB/IIA; 16%, stage IIB; 6%, stage III; and 6%, stage IV. Six patients received acitretin, with the other 26 assigned acitretin and another CTCL therapy, most commonly nitrogen mustard among the 19 responders.







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